Prof. (Emeritus) Malka Cohen-Armon
Research work
Signal transduction; immediate early gene expression; Electrical stimulation inducing chromatin modification
My majore interest is in disclosing the role of chromatin modifications in synaptic plasticity
Areas of interest & scientific knowledge
Behavioral Neuroscience
Cellular & Molecular Neuroscience
Cognitive Neuroscience
Selected Publications
- Cohen-Armon M., Visochek L., Katzoff A., Levitan D., Susswein A.J., Klein R.,Valbrun M., and Schwartz J.H. 2004. Long-term memory requires polyADP- ribosylation. Science 304: 1820-1823 Editorials: ‘DNA damage and Long-Term Memory‘, Science 304:1715, 2004 Neuronal plasticity: PARP1 allows lasting memories Nature Rev. Neurosci. 5, 597 200
- Cohen-Armon M., Visochek L., Rozensal D., Kalal A., Klein R., Bendetz- Netzer S., Yao Z., and Seger R. 2007. DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: A link to histone acetylation. Mol Cell 2007, 25: 297-308
- Visochek L, Kalal A, GrigoryanG, Milshtein-Parush H, Gazit N, Slutsky I, Yecheskel A., Shainberg A,Castiel A, Seger R., Langelier M.F., Dantzer F, Pascal J., Segal M, Cohen-Armon M. 2016. A PARP1-ERK2 synergism is required for the induction of LTP. Sci. Rep(Nature) 6, 24950; doi: 10.1038/srep24950
- Elad Lax, Alexander Friedman, Renaud Massart, Royi Barnea, Lital Abraham, Leonid Visochek, Matthew Suderman, Malka Cohen-Armon, Moshe Szyf and Gal Yadid, PARP-1 is Required for Retrieval of Cocaine-Associated Memory by Binding to the Promoter of a Novel Gene Encoding a Putative Transposase Inhibitor. Molecular Psychiatry volume 22, pages570–579(2017) doi: 10.1038/mp.2016.119 Patent: "Treatment of addiction" application 13/761,761, granted Oct 2014 US 08889707B1
- Malka Cohen-Armon, Adva Yeheskel, John M.Pascal. 2019. A signal-induced PARP1-Erk synergism mediates IEG expression. Review submitted to Signal Transduction and Targeted Therapy (Nature) 8;4.org/10.1038/s41392-019-0042-0
